Particularly, compound 95 served as probably the most efficacious with the shortlisted compounds within an HCT116 tumor xenograft design, which also could inhibit The expansion of a broad panel of human cancer cell lines such as breast, ovarian, colon, prostate, lung and melanoma cell lines.-indazoles products using a wide purposeful group toleranc
Substitution at R3 having a halogen or alkoxy group (74f–74i) brought about a slight rise in cellular potency Together with the halide analogs (74g–h) exhibiting optimum the potency from the group. Even further optimization triggered the invention of 74i–j, with 74k as the most active compound inside the sequence (pIC50 = six.seventy seven) w
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